Cell Proliferation and Isotype Switching Germinal Center Reaction: Triggering of B Toward a Role of Dendritic Cells in the
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Further evidence for in vivo isotype switching in B-cell chronic lymphocytic leukemia.
In a recent article in Blood, Malison et a l l have reported experimental evidence in support of in vivo isotype switching in B-cell chronic lymphocytic leukemia (CLL). The evidence was that freshly isolated sIgM’ sIgGsIgK B-CLL cells nevertheless express IgG and IgA transcripts that have identical VDJ segments and that these cells may be induced in vivo to secrete IgG and IgA. Based on our own...
متن کاملBiology of germinal centers in lymphoid tissue.
Germinal centers in lymphoid tissue are the sites of generation of memory B cells undergoing isotype switching and somatic mutation in their Ig genes. Their formation cannot be induced by stimuli other than immunogenic ones. It seems likely that in the function and possibly also in the formation of germinal centers, one important factor is the localization of immune complexes with fixed complem...
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Background: Dendritic cells (DCs) are the most potent stimulators of primary T cell responses and play a key role in immune reactions after stem cell transplantation. Very little is known about the cord blood (CB) dendritic cells and their potential involvement in the low incidence and lower severity of acute graft-versus-host disease after CB transplantation. Objectives: The aim of this stud...
متن کاملThe dendritic cell-specific CC-chemokine DC-CK1 is expressed by germinal center dendritic cells and attracts CD38-negative mantle zone B lymphocytes.
DC-CK1 (CCL18) is a dendritic cell (DC)-specific chemokine expressed in both T and B cell areas of secondary lymphoid organs that preferentially attracts CD45RA(+) T cells. In this study, we further explored the nature of DC-CK1 expressing cells in germinal centers (GCs) of secondary lymphoid organs using a newly developed anti-DC-CK1 mAb. Immunohistochemical analysis demonstrated a remarkable ...
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Abstract Background and objectives: Dendritic Cells are the most important of antigen presenting cells with an effective role in immune tolerance. This study, aims to clarify the role of IFN- β in induction on dendritic cells derived by monocyte in diabetes type1 to evaluate the T cells response to beta cell specific antigenic molecule. Material and Methods: In this research, peripheral bl...
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